BDNF Serum Levels in Alzheimer’s Disease and Mild Cognitive Impairment
نویسندگان
چکیده
The mild cognitive impairment (MCI) group had higher brainderived neurotrophic factor (BDNF) levels as compared to the Alzheimer’s disease (AD) group, according to a study published by Journal of Psychiatry. Hyun Kim and Kang Joon Lee, Inje University Ilsanpaik Hospital, Goyang, South Korea, examined the differences in the serum BDNF levels in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) and normal controls. BDNF represents a potential neuroprotective agent useful in preventing neurodegeneration, as clearly demonstrated in animal models. In humans, however, the association of BDNF serum levels with the rate of cognitive decline is still unclear [1,2].
منابع مشابه
Differences in BDNF Serum Levels in Patients with Alzheimer’s Disease and Mild Cognitive Impairment
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline with loss of memory, speech, and executive function. The neuropathological features of AD include the formation of neuritic plaques due to the deposition of beta-amyloid protein and the formation of neurofibrillary tangles in the brain. Mild cognitive impairment (MCI) represents a transitional state betw...
متن کاملBrain-Derived Neurotrophic Factor Serum Levels and Hippocampal Volume in Mild Cognitive Impairment and Dementia due to Alzheimer Disease
BACKGROUND/AIMS Hippocampal atrophy is a recognized biomarker of Alzheimer disease (AD) pathology. Serum brain-derived neurotrophic factor (BDNF) reduction has been associated with neurodegeneration. We aimed to evaluate BDNF serum levels and hippocampal volume in clinical AD (dementia and mild cognitive impairment [MCI]). METHODS Participants were 10 patients with MCI and 13 with dementia du...
متن کاملBrain-derived neurotrophic factor serum levels correlate with cognitive performance in Parkinson’s disease patients with mild cognitive impairment
Brain-derived neurotrophic factor (BDNF) is a trophic factor regulating cell survival and synaptic plasticity. Recent findings indicate that BDNF could be a potential regulatory factor for cognitive functioning in normal and/or neuropathological conditions. With regard to neurological disorders, recent data suggest that individuals with Parkinson's disease (PD) may be affected by cognitive defi...
متن کاملBrain-derived Neurotrophic Factor Is Associated with Cognitive Impairment in Elderly Korean Individuals
OBJECTIVE Brain-derived neurotrophic factor (BDNF) is a neurotrophin that is widely expressed in the mammalian brain and acts to regulate neuronal survival and influence cognitive processes. The present study measured serum BDNF levels to investigate the associations of the BDNF Val66Met and 5-hydroxytryptamine transporter linked promoter region (5-HTTLPR) polymorphisms with cognitive function ...
متن کاملSerum Eicosapentaenoic and Arachidonic Acids Concentration and Cognitive Function in Patients With Coronary Artery Disease
Introduction: Recent studies have shown that Polyunsaturated Fatty Acids (PUFAs), including Eicosapentaenoic Acid (EPA), and Arachidonic Acid (AA), are associated with cognitive functions in patients with Coronary Artery Disease (CAD). Nevertheless, controversial results have been reported, too. The current study aimed to clarify the association of serum EPA and AA levels with cognitive decline...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2016